{"id":9,"date":"2019-03-19T18:46:16","date_gmt":"2019-03-19T09:46:16","guid":{"rendered":"http:\/\/murakami-lab.bs.teu.ac.jp\/?page_id=9"},"modified":"2026-03-30T09:57:25","modified_gmt":"2026-03-30T00:57:25","slug":"%e7%a0%94%e7%a9%b6%e5%86%85%e5%ae%b9","status":"publish","type":"page","link":"https:\/\/murakami-lab.bs.teu.ac.jp\/?page_id=9","title":{"rendered":"\u7814\u7a76\u5185\u5bb9 Research"},"content":{"rendered":"\n

\u304c\u3093\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u7570\u5e38\u3068\u7d30\u80de\u6a5f\u80fd\u306e\u95a2\u4fc2\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u89e3\u660e\u3057\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u306e\u5275\u51fa\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u5408\u6210\u81f4\u6b7b\u306e\u6982\u5ff5\u3092\u57fa\u76e4\u3068\u3057\u3066\u3001\u304c\u3093\u7d30\u80de\u7279\u6709\u306e\u5f31\u70b9\u3092\u6a19\u7684\u3068\u3059\u308b\u7814\u7a76\u3092\u63a8\u9032\u3057\u3066\u304a\u308a\u3001\u4f4e\u5206\u5b50\u5316\u5408\u7269\u3084\u6838\u9178\u533b\u85ac\uff08siRNA\uff09\u3092\u7528\u3044\u305f\u5fdc\u7528\u7814\u7a76\u304b\u3089\u3001\u5206\u88c2\u9175\u6bcd\u3092\u30e2\u30c7\u30eb\u3068\u3057\u305f\u57fa\u790e\u7814\u7a76\u307e\u3067\u3001\u5e45\u5e83\u304f\u5c55\u958b\u3057\u3066\u3044\u307e\u3059\u3002

[\u4e3b\u306a\u7814\u7a76\u30c6\u30fc\u30de]
1. \u60aa\u6027\u4e2d\u76ae\u816b\u306b\u304a\u3051\u308b\u539f\u56e0\u907a\u4f1d\u5b50\u5909\u7570\u3068\u306e\u5408\u6210\u81f4\u6b7b\u306b\u57fa\u3065\u304f\u7d30\u80de\u5897\u6b96\u6a5f\u69cb\u306e\u89e3\u660e
2.\u5408\u6210\u81f4\u6b7b\u306b\u57fa\u3065\u304d\u3001\u4f4e\u5206\u5b50\u5316\u5408\u7269\u304a\u3088\u3073siRNA\u3092\u7528\u3044\u3066\u3001\u304c\u3093\u7d30\u80de\u7279\u7570\u7684\u306a\u8106\u5f31\u6027\u3092\u6a19\u7684\u3068\u3059\u308b\u6297\u304c\u3093\u6226\u7565\u306e\u958b\u767a
3. DNA\u8907\u88fd\u30fb\u4fee\u5fa9\u304a\u3088\u3073\u7d30\u80de\u5468\u671f\u5236\u5fa1\u306e\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\uff08\u5206\u88c2\u9175\u6bcd\u30e2\u30c7\u30eb\u3092\u542b\u3080\uff09<\/p>\n\n\n\n

\u7814\u7a76\u7d39\u4ecb\u306b\u3064\u3044\u3066\u306f\u3001\u4ee5\u4e0b\u306e\u30da\u30fc\u30b8\u3082\u3054\u89a7\u304f\u3060\u3055\u3044\u3002

\u5408\u6210\u81f4\u6b7b\u3092\u57fa\u76e4\u3068\u3057\u305f\u304c\u3093\u7814\u7a76\u306b\u8208\u5473\u3092\u6301\u3061\u3001\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u304b\u3089\u5275\u85ac\u5fdc\u7528\u307e\u3067\u5e45\u5e83\u304f\u53d6\u308a\u7d44\u307f\u305f\u3044\u610f\u6b32\u7684\u306a\u5b66\u751f\u306e\u53c2\u52a0\u3092\u6b53\u8fce\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

Decoding cancer vulnerabilities through synthetic lethality\u2014from yeast to therapy<\/strong>
We conduct research aimed at elucidating the molecular relationships between genetic alterations and cellular functions in cancer, with the ultimate goal of developing novel therapeutic strategies. In particular, our work is centered on the concept of synthetic lethality, focusing on identifying and targeting vulnerabilities specific to cancer cells. Our research spans a broad range of approaches, from applied studies using small molecules and nucleic acid therapeutics (siRNA) to fundamental studies employing fission yeast as a model system.

[Main Research Topics]
1. Elucidation of cell proliferation mechanisms based on synthetic lethality associated with driver gene mutations in malignant mesothelioma
2. Development of synthetic lethality-based anti-cancer strategies targeting cancer cell-specific vulnerabilities using small molecules and siRNA
3. Elucidation of the molecular mechanisms underlying DNA replication, DNA repair, and cell cycle regulation, including studies using fission yeast models<\/p>\n\n\n\n

For more information about our research, please see the pages below.

We welcome motivated students interested in exploring cancer vulnerabilities through synthetic lethality, from basic molecular mechanisms to therapeutic applications.<\/p>\n\n\n\n



\u751f\u547d\u79d1\u5b66\u30fb\u533b\u85ac\u54c1\u30bb\u30df\u30ca\u30fc#2<\/a>\u306b\u7814\u7a76\u7d39\u4ecb\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u5927\u5b66\u306e\u5b66\u3073\u306f\u3053\u3093\u306a\u306b\u9762\u767d\u3044\uff08\u7814\u7a76\u30fb\u6559\u80b2\u7d39\u4ecb\uff09\u300c\u907a\u4f1d\u5b66\u306e\u624b\u6cd5\u3092\u7528\u3044\u305f\u65b0\u3057\u3044\u6297\u304c\u3093\u5264\u3084\u304c\u3093\u306e\u8ee2\u79fb\u3092\u65e9\u671f\u767a\u898b\u3059\u308b\u691c\u67fb\u624b\u6cd5\u306e\u958b\u767a\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\uff01\u300d<\/a><\/p>\n\n\n\n

\u6cb3\u5408\u587eKei-Net\u306e\u7814\u7a76\u5ba4\u30bc\u30df\u7d39\u4ecb<\/a>\u306b\u3082\u7814\u7a76\u7d39\u4ecb\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

2022\/11\/5\u306b\u767a\u8868\u3057\u305f\u8ad6\u6587\u306b\u3064\u3044\u3066\u3001\u5927\u5b66HP<\/a>\u3067\u7d39\u4ecb\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u304c\u3093\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u7570\u5e38\u3068\u7d30\u80de\u6a5f\u80fd\u306e\u95a2\u4fc2\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u89e3\u660e\u3057\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u306e\u5275\u51fa\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u5408\u6210\u81f4\u6b7b\u306e\u6982\u5ff5\u3092\u57fa\u76e4\u3068\u3057\u3066\u3001\u304c\u3093\u7d30\u80de\u7279\u6709\u306e\u5f31\u70b9\u3092\u6a19\u7684\u3068\u3059\u308b\u7814\u7a76\u3092\u63a8\u9032\u3057\u3066\u304a\u308a\u3001\u4f4e\u5206\u5b50\u5316\u5408\u7269\u3084\u6838\u9178\u533b\u85ac\uff08s … <\/p>\n

“\u7814\u7a76\u5185\u5bb9 Research” \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/9","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9"}],"version-history":[{"count":25,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":731,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/9\/revisions\/731"}],"wp:attachment":[{"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}