{"id":780,"date":"2026-08-23T08:37:11","date_gmt":"2026-08-22T23:37:11","guid":{"rendered":"https:\/\/murakami-lab.bs.teu.ac.jp\/?p=780"},"modified":"2026-08-23T15:12:09","modified_gmt":"2026-08-23T06:12:09","slug":"accepted","status":"publish","type":"post","link":"https:\/\/murakami-lab.bs.teu.ac.jp\/?p=780","title":{"rendered":"Accepted!"},"content":{"rendered":"\n<p><strong>\u8ad6\u6587\u304cBioorganic &amp; Medicinal Chemistry\u306b\u30a2\u30af\u30bb\u30d7\u30c8\u3055\u308c\u307e\u3057\u305f\uff01<\/strong><\/p>\n\n\n\n<p>\u65e5\u672c\u5927\u5b66\u6587\u7406\u5b66\u90e8\u306e\u65e9\u5ddd\u4e00\u90ce\u5148\u751f\u3001\u540d\u53e4\u5c4b\u5927\u5b66\u30c8\u30e9\u30f3\u30b9\u30d5\u30a9\u30fc\u30de\u30c6\u30a3\u30d6\u751f\u547d\u5206\u5b50\u7814\u7a76\u6240\uff08ITbM\uff09\u306e\u4f50\u85e4\u7dbe\u4eba\u5148\u751f\u3068\u306e\u5171\u540c\u7814\u7a76\u306b\u3088\u308b\u8ad6\u6587<br>\u201cSynthesis and biological evaluation of optically active Z250\u20131659 as a synthetic lethal agent against BAP1-deficient mesothelioma cells\u201d<br>\u304c\u3001<em>Bioorganic &amp; Medicinal Chemistry<\/em> \u306b\u30a2\u30af\u30bb\u30d7\u30c8\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u79c1\u305f\u3061\u306f\u3053\u308c\u307e\u3067\u3001\u60aa\u6027\u4e2d\u76ae\u816b\u3067\u9ad8\u983b\u5ea6\u306b\u6a5f\u80fd\u3092\u5931\u3063\u3066\u3044\u308b\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50 BAP1 \u306b\u7740\u76ee\u3057\u3001BAP1\u3092\u6b20\u640d\u3057\u305f\u304c\u3093\u7d30\u80de\u306b\u9078\u629e\u7684\u306b\u4f5c\u7528\u3059\u308b\u5316\u5408\u7269\u3092\u63a2\u7d22\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u305d\u306e\u904e\u7a0b\u3067\u3001\u540d\u53e4\u5c4b\u5927\u5b66ITbM\u306e\u5316\u5408\u7269\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u304b\u3089 Z250-1659 \u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001Z250-1659\u306e\u5149\u5b66\u7570\u6027\u4f53\u3092\u65e9\u5ddd\u5148\u751f\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u5408\u6210\u3057\u3066\u3044\u305f\u3060\u304d\u3001\u305d\u306e\u751f\u7269\u6d3b\u6027\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u30012\u3064\u306e\u5149\u5b66\u7570\u6027\u4f53\u306e\u3046\u3061\u3001\u4e3b\u3068\u3057\u3066\u4e00\u65b9\u306e S\u4f53 \u304cBAP1\u6b20\u640d\u4e2d\u76ae\u816b\u7d30\u80de\u306b\u5bfe\u3059\u308b\u5897\u6b96\u6291\u5236\u6d3b\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u6709\u6a5f\u5408\u6210\u5316\u5b66\u3068\u304c\u3093\u751f\u7269\u5b66\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u9032\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u7814\u7a76\u3067\u3059\u3002\u65e9\u5ddd\u5148\u751f\u3001\u4f50\u85e4\u5148\u751f\u3092\u306f\u3058\u3081\u3001\u7814\u7a76\u306b\u3054\u5354\u529b\u3044\u305f\u3060\u3044\u305f\u7686\u3055\u307e\u306b\u5fc3\u3088\u308a\u611f\u8b1d\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u3057\u3066\u3001\u3053\u306e\u5316\u5408\u7269\u306e\u7814\u7a76\u306f\u3053\u308c\u3067\u7d42\u308f\u308a\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u73fe\u5728\u306f\u3001Z250-1659\u304c\u3069\u306e\u3088\u3046\u306a\u5206\u5b50\u6a5f\u69cb\u306b\u3088\u3063\u3066BAP1\u6b20\u640d\u304c\u3093\u7d30\u80de\u306b\u4f5c\u7528\u3059\u308b\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u3001\u751f\u7269\u5b66\u7684\u306a\u89e3\u6790\u3092\u3055\u3089\u306b\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306e\u8ad6\u6587\u306b\u7d9a\u3044\u3066\u3001\u3053\u3061\u3089\u3082\u8ad6\u6587\u3068\u3057\u3066\u5831\u544a\u3067\u304d\u308b\u3088\u3046\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u304d\u307e\u3059\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8ad6\u6587\u304cBioorganic &amp; Medicinal Chemistry\u306b\u30a2\u30af\u30bb\u30d7\u30c8\u3055\u308c\u307e\u3057\u305f\uff01 \u65e5\u672c\u5927\u5b66\u6587\u7406\u5b66\u90e8\u306e\u65e9\u5ddd\u4e00\u90ce\u5148\u751f\u3001\u540d\u53e4\u5c4b\u5927\u5b66\u30c8\u30e9\u30f3\u30b9\u30d5\u30a9\u30fc\u30de\u30c6\u30a3\u30d6\u751f\u547d\u5206\u5b50\u7814\u7a76\u6240\uff08ITbM\uff09\u306e\u4f50\u85e4\u7dbe\u4eba\u5148\u751f\u3068\u306e\u5171\u540c\u7814\u7a76 &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/murakami-lab.bs.teu.ac.jp\/?p=780\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;Accepted!&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-780","post","type-post","status-publish","format-standard","hentry","category-3"],"_links":{"self":[{"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/780","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=780"}],"version-history":[{"count":2,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/780\/revisions"}],"predecessor-version":[{"id":785,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/780\/revisions\/785"}],"wp:attachment":[{"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}