{"id":800,"date":"2026-09-16T10:18:07","date_gmt":"2026-09-16T01:18:07","guid":{"rendered":"https:\/\/murakami-lab.bs.teu.ac.jp\/?p=800"},"modified":"2026-09-16T10:18:07","modified_gmt":"2026-09-16T01:18:07","slug":"%e4%b8%ad%e7%9a%ae%e8%85%ab%e3%81%ab%e9%81%b8%e6%8a%9e%e7%9a%84%e3%81%ab%e4%bd%9c%e7%94%a8%e3%81%99%e3%82%8b%e5%8c%96%e5%90%88%e7%89%a9%e3%81%a8%e5%85%89%e5%ad%a6%e7%95%b0%e6%80%a7%e4%bd%93%e3%81%ab","status":"publish","type":"post","link":"https:\/\/murakami-lab.bs.teu.ac.jp\/?p=800","title":{"rendered":"\u4e2d\u76ae\u816b\u306b\u9078\u629e\u7684\u306b\u4f5c\u7528\u3059\u308b\u5316\u5408\u7269\u3068\u5149\u5b66\u7570\u6027\u4f53\u306b\u95a2\u3059\u308b\u7814\u7a76\u6210\u679c\u3092\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u3057\u307e\u3057\u305f"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u5f53\u7814\u7a76\u5ba4\u3068\u65e5\u672c\u5927\u5b66\u3001\u540d\u53e4\u5c4b\u5927\u5b66\u306e\u5171\u540c\u7814\u7a76\u6210\u679c\u306b\u3064\u3044\u3066\u3001\u672c\u65e5\u3001\u5171\u540c\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u3067\u306f\u3001BAP1\u5909\u7570\u3092\u6709\u3059\u308b\u60aa\u6027\u4e2d\u76ae\u816b\u7d30\u80de\u306b\u9078\u629e\u7684\u306a\u5897\u6b96\u6291\u5236\u6d3b\u6027\u3092\u793a\u3059\u5316\u5408\u7269Z250-1659\u306b\u3064\u3044\u3066\u5149\u5b66\u7570\u6027\u4f53\u3092\u5408\u6210\u3057\u3001\u305d\u306e\u6d3b\u6027\u304c\u4e3b\u3068\u3057\u3066(S)-\u4f53\u306b\u7531\u6765\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u6210\u679c\u306f\u3001Bioorganic &amp; Medicinal Chemistry\u306b\u63b2\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8a73\u7d30\u306f\u6771\u4eac\u5de5\u79d1\u5927\u5b66\u306e\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.teu.ac.jp\/press\/2026.html?id=225\" target=\"_blank\" rel=\"noopener\">\u6771\u4eac\u5de5\u79d1\u5927\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u300c\u4e2d\u76ae\u816b\u306b\u9078\u629e\u7684\u306b\u4f5c\u7528\u3059\u308b\u5316\u5408\u7269\u3068\u5149\u5b66\u7570\u6027\u4f53\u3092\u7279\u5b9a\u300d<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8ad6\u6587<\/strong><br>Tsutsumi T, Wada A, Yamamoto H, et al.<br>\u201cSynthesis and biological evaluation of optically active Z250\u20131659 as a synthetic lethal agent against BAP1-deficient mesothelioma cells\u201d<br>Bioorganic &amp; Medicinal Chemistry, 143, 118782 (2026).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0968089626002385\" target=\"_blank\" rel=\"noopener\">\u8ad6\u6587\uff08DOI\uff09<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5f53\u7814\u7a76\u5ba4\u3068\u65e5\u672c\u5927\u5b66\u3001\u540d\u53e4\u5c4b\u5927\u5b66\u306e\u5171\u540c\u7814\u7a76\u6210\u679c\u306b\u3064\u3044\u3066\u3001\u672c\u65e5\u3001\u5171\u540c\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002 \u672c\u7814\u7a76\u3067\u306f\u3001BAP1\u5909\u7570\u3092\u6709\u3059\u308b\u60aa\u6027\u4e2d\u76ae\u816b\u7d30\u80de\u306b\u9078\u629e\u7684\u306a\u5897\u6b96\u6291\u5236\u6d3b\u6027\u3092\u793a\u3059\u5316\u5408\u7269Z250-1659\u306b\u3064\u3044\u3066\u5149\u5b66\u7570\u6027\u4f53\u3092\u5408\u6210\u3057 &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/murakami-lab.bs.teu.ac.jp\/?p=800\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;\u4e2d\u76ae\u816b\u306b\u9078\u629e\u7684\u306b\u4f5c\u7528\u3059\u308b\u5316\u5408\u7269\u3068\u5149\u5b66\u7570\u6027\u4f53\u306b\u95a2\u3059\u308b\u7814\u7a76\u6210\u679c\u3092\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u3057\u307e\u3057\u305f&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-800","post","type-post","status-publish","format-standard","hentry","category-1"],"_links":{"self":[{"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/800","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=800"}],"version-history":[{"count":1,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/800\/revisions"}],"predecessor-version":[{"id":801,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/800\/revisions\/801"}],"wp:attachment":[{"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=800"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=800"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/murakami-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=800"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}